News

The latest updates from our laboratory.

Two theses defended in Applied Chemistry and Gene Technology

Congratulations to Triinu Rätsepso and Merili Samuli on defending their theses in the Applied Chemistry and Gene Technology programme.

Triinu defended her master's thesis, The creatine analogue guanidinoacetate does not stimulate respiration in permeabilized mouse cardiomyocytes. Her work exam...

Published paper: Lifelong creatine deficiency does not cause heart failure

Lifelong creatine deficiency leads to augmented sarcoplasmic reticulum calcium release but not heart failure

Jelena Branovets, Martin Laasmaa, Jekaterina Stolova, Xin Shen, Triinu Rätsepso, Romain Bernasconi, Kärol Soodla, Mihkel Jaan Balodis, Cärolin Grahv, Eliise Hendrikson, William Edward Louch...

Published paper: How creatine deficiency changes heart energy transfer

Cardiac expression and location of hexokinase changes in a mouse model of pure creatine deficiency

Jelena Branovets, Niina Karro, Karina Barsunova, Martin Laasmaa, Craig A Lygate, Marko Vendelin, Rikke Birkedal

Am J Physiol Heart Circ Physiol, 2021 Feb 01; 320(2): H613-H629.

Published paper: Creatine-deficiency models reveal distinct muscle effects

Marker enzyme activities in hindleg from creatine-deficient AGAT and GAMT KO mice - differences between models, muscles, and sexes

Karina Barsunova, Marko Vendelin, Rikke Birkedal

Sci Rep, 2020 May 14; 10(1): 7956.

Significance

Creati...